I have the VERY same two questions!
Can we set somehow to always save on the desktop by default instead of current file's dir?
My syntaxes are now all set (was difficult to have them work), and, in my case, it is set to AutoHotKey. However, I'd like to have Sublime always assume I'm writing a .txt file to be saved in the desktop by default (thus automatically appending the .txt extension) and do not apply the AHK syntax unless I save with the .ahk extension for the first time. Is it possible?