Of use sometimes is to use Ctrl-Alt-down to multi-select the next column downwards - at least it goes straight-down and you can press Escape (without typing anything!) once you've checked the alignment.
(It does jump to the left if there is a blank line, and to the right if there is a line-wrap, but still..)
Edited: Or for a block, select the block and press Ctrl-Shift-L, then Home to jump to the front of all the lines. Don't forget to press Escape, or click out, once you've checked. Edited2: Press Home twice so that you can start from the very beginning (far left).