This was mentioned way back in 2011 ( possibly later), but as it's still an issue with the latest stable release I thought I'd bring it up again.
After installing the
anaconda package, the global
Preferences option in ST3 is grayed out. This issue is intermittent, but seems to be correlated with enabling/disabling the package. For an otherwise amazing editor, this seems like a rather large bug. Hoping to see it get addressed by tech support, thanks for all your great work!