Eugh, I hate it when plugins stop working because someone added a new setting. Such a pain. Personally, I think it is really weird and annoying that most plugins in sublime default to being off. Why would I install a plugin if I didn't want to use it. Plugins should default to being on.
You need parentheses on line 166. You could have a situation like not True and False which is interpreted as (not True) and False but you want not (True and False) so that it gets in the if.
Also, I don't like that when I select text, all indent guides go away. I actually used that a good bit in my 76 space indent to select the correct text.